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Background  Chondrocytes are regularly exposed to load-induced stimuli and have the capability to sense and respond to applied mechanical stress. However, the mechanisms involved in chondrocyte mechanotransduction are not clearly understood. The purpose of this study was to explore the effects of cyclic equibiaxial mechanical stretch on the expression of α-BK and TRPV4 channels.    Findings  Freshly isolated equine articular chondrocytes were subjected to mechanical stress (8% elongation at frequency of 0.5 Hz for 8 h). Western blotting was used to investigate the expression of BK Ca  and TRPV4 channel proteins. Mechanical stretch increased the expression of BK Ca  channels by 1.8 fold but TRPV4 expression was not affected.    Conclusions  Upregulation of BK Ca  channel may be the result of direct membrane stretch or elevated intracellular Ca 2+ .

Effects of cyclic equibiaxial mechanical stretch on α-BK and TRPV4 expression in equine chondrocytes