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There are various methods for detection of  Helicobacter pylori  and the gold standard for non-invasive detection is the urea breath test (UBT). The aim of the study is therefore to detect  H. pylori  from the stool of patients with dyspepsia by PCR and compare results obtained with UBT. A total of 97 stool samples from patients presenting with dyspeptic symptoms in Lagos University Teaching Hospital (LUTH) were screened for urea breath test (UBT) and the presence of  H. pylori  DNA using stool-PCR. Out of 97 stool samples analysed, 38 (39.2%) were positive for  Helicobacter  spp. and 20 (20.6%) positive for  H. pylori  by PCR, through amplification of 16S rRNA and  glmM genes respectively. Of the 20 positive by  glm M gene, the  cagA gene was detected in 8 (40%) samples, while 47 (48.5%) out of 97 stool samples were positive for  H. pylori  by UBT. The sensitivity and specificity of the  glmM  gene compared with UBT as the gold standard is 42.6% and 100% respectively. The positive predictive value (PPV) was 100% while the negative predictive value (NPV) was 60%.The method may be useful for detecting  H. pylori  from stool amongst children especially where most hospitals lack endoscope for children although the method is expensive.

Application of stool-PCR for the diagnosis of Helicobacter pylori from stool in Nigeria- a pilot study