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In intensive care for sepsis, damage of intracellular environmental states is responsible for not only infectious disease severity but also oxidative DNA damage following hypometabolism such as hypoxia, hypotension, hypothermia, and hypoglycemia. Therefore, identification of a biomarker to monitor these intracellular equilibrium conditions is crucial for the prognosis of disease severity. Under an environmental condition, the 8-oxodeoxyguanosine (8-OH-dG) levels in tissues were previously shown to be increased as a result of oxidative DNA damage. The purpose of this study was to elucidate whether the circulating 8-OH-dG levels may serve as a marker for severity in a mouse septic model.

Increased levels of circulating 8-oxodeoxyguanosine as a biomarker of sepsis severity in mice