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Background  The genus  Mycobacterium  comprises different species, among them the most contagious and infectious bacteria. The members of the complex  Mycobacterium tuberculosis  are the most virulent microorganisms that have killed human and other mammals since millennia. Additionally, with the many different mycobacterial sequences available, there is a crucial need for the visualization and the simplification of their data. In this present study, we aim to highlight a comparative genome, proteome and phylogeny analysis between twenty-one mycobacterial (Tuberculosis and non tuberculosis) strains using a set of computational and bioinformatics tools (Pan and Core genome plotting, BLAST matrix and phylogeny analysis).    Results  Considerably the result of pan and core genome Plotting demonstrated that less than 1250  Mycobacterium  gene families are conserved across all species, and a total set of about 20,000 gene families within the  Mycobacterium  pan-genome of twenty one mycobacterial genomes.  Viewing the BLAST matrix a high similarity was found among the species of the complex  Mycobacterium tuberculosis  and less conservation is found with other slow growing pathogenic mycobacteria.  Phylogeny analysis based on both protein conservation, as well as rRNA clearly resolve known relationships between slow growing mycobacteria.    Conclusion  Mycobacteria include important pathogenic species for human and animals and the  Mycobacterium tuberculosis  complex is the most cause of death of the humankind. The comparative genome analysis could provide a new insight for better controlling and preventing these diseases.

Computational genomics-proteomics and Phylogeny analysis of twenty one mycobacterial genomes (Tuberculosis & non Tuberculosis strains)