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Background and the purpose of the study   Boswellia carterii have  been used in traditional medicine for many years for management different gastrointestinal disorders. In this study, we wish to report urease inhibitory activity of four isolated compound of boswellic acid derivative.    Methods  4 pentacyclic triterpenoid acids were isolated from  Boswellia carterii  and identified by NMR and Mass spectroscopic analysis (compounds  1 , 3-O-acetyl-9,11-dehydro-β-boswellic acid;  2 , 3-O-acetyl-11-hydroxy-β-boswellic acid;  3 . 3-O- acetyl-11-keto-β-boswellic acid and  4 , 11-keto-β-boswellic acid. Their inhibitory activity on Jack bean urease were evaluated. Docking and pharmacophore analysis using AutoDock 4.2 and Ligandscout 3.03 programs were also performed to explain possible mechanism of interaction between isolated compounds and urease enzyme.    Results  It was found that compound  1  has the strongest inhibitory activity against Jack bean urease (IC 50  = 6.27 ± 0.03 μM), compared with thiourea as a standard inhibitor (IC 50  = 21.1 ± 0.3 μM).    Conclusion  The inhibition potency is probably due to the formation of appropriate hydrogen bonds and hydrophobic interactions between the investigated compounds and urease enzyme active site and confirms its traditional usage.

Urease inhibitory activities of β-boswellic acid derivatives