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Background and purpose of the study   H. pylori  infection is an important etiologic impetus usually leading to gastric disease and urease enzyme is the most crucial role is to protect the bacteria in the acidic environment of the stomach. Then urease inhibitors would increase sensitivity of the bacteria in acidic medium.    Methods  137 Iranian traditional medicinal plants were examined against Jack bean urease activity by Berthelot reaction. Each herb was extracted using 50% aqueous methanol. The more effective extracts were further tested and their IC 50  values were determined.    Results  37 plants out of the 137 crude extracts revealed strong urease inhibitory activity (more than 70% inhibition against urease activity at 10 mg/ml concentration). Nine of the whole studied plants crude extracts were found as the most effective with IC 50  values less than 500 μg/ml including;  Rheum ribes, Sambucus ebulus, Pistachia lentiscus, Myrtus communis, Areca catechu, Citrus aurantifolia, Myristica fragrans, Cinnamomum zeylanicum  and  Nicotiana tabacum.Conclusions  The most potent urease inhibitory was observed for  Sambucus ebulus  and  Rheum ribes  extracts with IC 50  values of 57 and 92 μg/ml, respectively.

Large scale screening of commonly used Iranian traditional medicinal plants against urease activity