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Two new cycloartane-type triterpene glycosides, namely cimicifoetisides A ( 1 ) and B ( 2 ), along with seven known compounds cimigenol, 25- O -acetylcimigenol, cimigenol 3- O -β-D-xylopyranoside, 12β-hydroxycimigenol 3- O -β-D-xylopyranoside, cimigenol 3- O -α-L-arabinopyranoside, 25-deoxyshengmanol 3- O -β-D-xylopyranoside and cimilactone A, were isolated from the rhizomes of  Cimicifuga foetida . Their structures were elucidated as cimigenol 3- O -(2'- O -acetyl)-α-L-arabinopyranoside ( 1 ) and 25- O -acetylcimigenol 3- O -(2'- O -acetyl)-α-L-arabinopyranoside ( 2 ). Both compounds  1  and  2  exhibited potent cytotoxicity against rat EAC (Ehrlich ascites carcinoma) and MDA-MB-A231 (human breast cancer) cells with IC 50  values of 0.52 and 6.74 μM for  1 , and 0.19 and 10.21 μM for  2 , suggesting their potential for further investigation as anti-cancer agents.

beilstein journal of organic chemistry

Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of <i>Cimicifuga foetida</i>, inhibit proliferation of cancer cells

Cimicifoetisides A and B, two cytotoxic cycloartane triterpenoid glycosides from the rhizomes of Cimicifuga foetida, inhibit proliferation of cancer cells