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Background  Dynamic changes to the chromatin structure play a critical role in transcriptional regulation. This is exemplified by the Spt6-mediated histone deposition on to histone-depleted promoters that results in displacement of the general transcriptional machinery during transcriptional repression.    Results  Using the yeast  PHO5  promoter as a model, we have previously shown that blocking Spt6-mediated histone deposition on to the promoter leads to persistent transcription in the apparent absence of transcriptional activators  in vivo . We now show that the nucleosome-depleted  PHO5  promoter and its associated transcriptionally active state can be inherited through DNA replication even in the absence of transcriptional activators. Transcriptional reinitiation from the nucleosome-depleted  PHO5  promoter in the apparent absence of activators  in vivo  does not require Mediator. Notably, the epigenetic inheritance of the nucleosome-depleted  PHO5  promoter through DNA replication does not require ongoing transcription.    Conclusion  Our results suggest that there may be a memory or an epigenetic mark on the nucleosome-depleted  PHO5  promoter that is independent of the transcription apparatus and maintains the promoter in a nucleosome-depleted state through DNA replication.

epigenetics and chromatin

Epigenetic inheritance of an inducibly nucleosome-depleted promoter and its associated transcriptional state in the apparent absence of transcriptional activators