English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Background  There is no published information about the use of different protocols to administer a highly diluted medication.  Evaluate the effect of different protocols for treatment with biotherapic  T. cruzi  17 dH (BIOT  Tc 17dH ) on clinical/parasitological evolution of mice infected with  T. cruzi-Y  strain.    Methods  A blind, randomized controlled trial was performed twice, using 60 28-day-old male Swiss mice infected with  T. cruzi-Y  strain, in five treatment groups: CI  -  treated with a 7% ethanol-water solution, diluted in water (10 μL/mL)  ad libitum ;  BIOT   PI   - treated with BIOT  Tc 17dH  in water (10 μL/mL)  ad libitum  during a period that started on the day of infection;  BIOT   4DI   - treated with BIOT  Tc 17dH  in water (10 μL/mL)  ad libitum  beginning on the 4 th  day of infection;  BIOT   4-5–6   - treated with BIOT  Tc 17dH  by gavage (0.2 mL/ animal/day) on the 4 th , 5 th  and 6 th  days after infection;  BIOT   7-8–9   - treated with BIOT  Tc 17dH  by gavage (0.2 mL/ animal/day) on the 7 th , 8 th  and 9 th  days after infection. We evaluated: parasitemia; total parasitemia (P total ); maximum peak of parasites; prepatent period (PPP) - time from infection to detection of the parasite in blood; patent period (PP) - period when the parasitemia can be detected in blood; clinical aspects; and mortality.    Results  Parasitological parameters in the BIOT PI  and mainly in the BIOT 4PI  group showed better evolution of the infection compared to the control group (CI), with lower P total , lower maximum peak of parasites, higher PPP, lower PP and longer survival times. These animals showed stable body temperature and higher weight gain and water consumption, with more animals having normal-appearing fur for longer periods. In contrast, groups BIOT 4-5–6  and BIOT 7-8–9  showed worse evolution of the infection compared to the control group, considering both parasitological and clinical parameters. The correlation analysis combined with the other data from this study indicated that the prepatent period is the best parameter to evaluate the effect of a medication in this model.    Conclusions  The BIOT 4DI  group showed the best clinical and parasitological evolution, with lower parasitemia and a trend toward lower mortality and a longer survival period. The prepatent period was the best parameter to evaluate the effect of a medication in this model.

Highly diluted medication reduces parasitemia and improves experimental infection evolution by Trypanosoma cruzi