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Background   ZAP70  gene expression is associated with poor prognosis in B-cell lymphoproliferative disorders especially chronic lymphocytic leukaemia (CLL) but its role in adult B-ALL has not been established. On diagnostic samples from 76 patients with adult ALL (65 with B-ALL and 11 with T-ALL)  ZAP70  mRNA expression levels were studied by real time-quantitative PCR (RT-qPCR) analysis.    Findings  A broad distribution of  ZAP70  expression was observed in ALL, ranging from 0.002 to 5.3 fold that of the  ZAP70  positive Jurkat reference cell line. No association was observed between expression levels and the presence of specific cytogenetic abnormalities. Five cases, including one case of T-ALL, had  ZAP70  expression above the level of the Jurkat reference cell line.    Conclusions  Our results confirm the frequent expression of  ZAP70  in adult ALL. Limited comparisons made did highlight poor-risk patients with high  ZAP70  expression, but due to lack of clinical information on patient samples we were unable to directly assess the impact on disease prognosis.  ZAP-70  may be an important laboratory assay in adult ALL and further studies are warranted to study a potential correlation with cytogenetic and other genetic markers.

Analysis of ZAP70 expression in adult acute lymphoblastic leukaemia by real time quantitative PCR