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The chromosomal translocation (11;14)(q13;q32) rearranging the locus for cyclin D1 ( CCND1 ) to that of the immunoglobulin heavy chain ( IGH ) can be found in virtually all cases of mantle cell lymphoma (MCL), while other  CCND1  translocations are extremely rare. As  CCND1  overexpression and activation is a hallmark of MCL it is regarded as a central biological mechanism in the development and maintenance of this disease.  Here we present a patient initially diagnosed with chronic lymphocytic leukemia (CLL) where chromosome banding analysis revealed, among other aberrations, a translocation (11;22)(q13;q11.2). We show by fluorescence in situ hybridization (FISH) analysis that on chromosome 22 the immunoglobulin light chain lambda ( IGL ) is involved in this cytogenetic aberration. Additionally, we demonstrate the resulting overexpression of  CCND1  on the RNA and protein level, thereby consolidating the new diagnosis of a MCL-like B-cell neoplasia. Summing up, we described a rare case of t(11;22)(q13;q11.2) in a MCL-like neoplasia and showed that this aberration leads to an overexpression of  CCND1  which is regarded as a key biological feature in MCL. This case underlines the importance of cytogenetic analyses especially in atypical cases of B cell lymphomas.

A rare case of t(11;22) in a mantle cell lymphoma like B-cell neoplasia resulting in a fusion of IGL and CCND1: case report