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Background  Chalcone, an important intermediate of flavonoid synthetic pathway, has been shown to exhibit diverse biological and pharmacological activities such as anti- cancer, antioxidant, anti-inflammatory, etc.    Results  In this study, a novel series of chalcones fatty acid esters  5b-e  and  6b-e  have been synthesized via the reaction of the respective chalcones with either palmitic or stearic acid. Another related class of compounds comprising 2,3-disubstituted chalcones  7b-d  and  8b(b’)-d  as well as 2-amino-6-(substituted-phenyl)-4-substitutedphenyl-nicotinonitrile derivatives  9a,c,e  have been also prepared by both electrophilic and Michael addition reactions, respectively, with the corresponding chalcones. The structures of all compounds are confirmed via a wide range of spectroscopic techniques including IR,  1 H and  13 C NMR, and mass spectra. Significantly, all synthesized compounds have been tested for their promising antioxidant activities via utilization of 1,1-biphenyl-2-picrylhydrazyl as a free radical scavenging reagent. Surprisingly, the results demonstrated that compound  5e  (68.58% at C = 2 μg/ml) was more effective as an antioxidant agent than the ascorbic acid, a commonly used antioxidant. Furthermore, the role and contribution of different functional groups on the antioxidant activity of the synthesized chalcone derivatives are also probed and rationalized in terms of their electronic and structural effect.    Conclusion  Good activity was noted for chalcone fatty acid esters, with some members recorded higher antioxidant activity than ascorbic acid.

Synthesis, characterization and evaluation of antioxidant activities of some novel chalcones analogues