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Background  The role of “ Jun-Chen-Zuo-Shi ” (also known as “sovereign-minister-assistant-courier”) component herbs of Chinese medicine is not fully understood. This study aims to test the “ Jun-Chen-Zuo-Shi ” rule with the  QiShenYiQi  formula (QSYQ) on treating acute myocardial ischemia (AMI) by a network pharmacology approach.    Methods  An Acute Myocardial Ischemia (AMI) specific Organism Disturbed Network (AMI-ODN), was constructed by integrating data of disease-associated genes, protein-protein interaction and microarray experiments. A network-based index, Network Recovery Index for Organism Disturbed Network (NRI-ODN), was developed to measure the therapeutic efficacy of QSYQ and its ingredients,  i.e. , the ability to recover disturbed AMI network model back to normal state.    Results  The whole formula of QSYQ got a NRI-ODN score of 864.48, which outperformed all individual herbs. Additionally, the primary component herbs,  Radix Astragalus membranaceus  and  Radix Salvia miltiorrrhiza  showed NRI-DON score of 680.27 and 734.31 respectively, which meant a better performance to recover disturbed AMI network than the supplementary component herbs,  Panax notoginseng  and  Dalbergia sissoo  did (545.76 and 584.88, respectively).    Conclusion  AMI-ODN model and NRI-ODN identified the possible roles of “ Jun-Chen-Zuo-Shi ” component herbs of QSYQ in treating AMI at molecular network and pathway level.

Identifying roles of “Jun-Chen-Zuo-Shi” component herbs of QiShenYiQi formula in treating acute myocardial ischemia by network pharmacology