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Background  There are approximately five  Zhengs  reported in psoriatic patients. Systematic data collection and proper analysis for the classification of psoriasis have been lacking. This study aims to cluster the  Zhengs  in psoriatic patients based on the application of a checklist of traditional Chinese medicine (TCM) symptoms and signs followed by latent class analysis (LCA).    Methods  A cross-sectional study of 507 psoriatic patients aged above 10 years was performed in Yunnan Provincial Hospital of TCM and the First Affiliated Hospital of Kunming Medicine University from October 2010 to September 2011 using a TCM symptoms and signs checklist obtained from 16 TCM experts by the Delphi technique. LCA was applied to obtain the best fitted model for clustering of symptoms and signs that can be interpreted as underlying  Zhengs  of psoriasis.    Results  The LCA identified three  Zhengs :  dampness-heat Zheng  (35.1%);  blood heat Zheng  (34.7%); and  yin deficiency  and  blood dryness Zheng  (30.2%). The first  Zheng  was associated with winter, the second with male sex, old age, smoking, and drinking alcohol, and the third with outpatient status, which reflected a mild disease course.    Conclusions  In this study, 507 psoriasis patients were clustered into three  Zheng s, which had different associated factors.

Identifying the Zheng in psoriatic patients based on latent class analysis of traditional Chinese medicine symptoms and signs