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Background   Radix Polygoni Multiflori  is the dried root tuber of  Polygonum multiflorum  Thunb. (Fam. Polygonaceae). According to Chinese medicine theory, raw (R-RPM) and processed (P-RPM)  Radix Polygoni Multiflori  possess different properties. The present study investigates the differences in chemistry between raw and processed  Radix Polygoni Multiflori .    Methods  Five pairs of R-RPM and P-RPM as well as 15 commercial decoction pieces were analyzed with high performance liquid chromatography (HPLC) and mass spectrometry (MS).    Results  Two anthraquinones, namely emodin-8- O -(6'- O -malonyl)-glucoside and physcion-8- O -(6'- O -malonyl)-glucoside disappeared or decreased significantly and 2,3,5,4'-tetrahydroxystilbene-2- O - β - D -glucopyranoside, emodin-8- O - β - D -glucopyranoside and physcion-8- O - β - D -glucopyranoside decreased after the R-RPM samples being processed. On the other hand, the contents of emodin and physcion generally increased after processing.    Conclusion  The present study indicates that processing  Radix Polygoni Multiflori  may change the contents and types of chemicals in it. These changes are probably responsible for the various pharmacological effects of R-RPM and P-RPM as well as hepatotoxicity.

Comparison of raw and processed Radix Polygoni Multiflori (Heshouwu) by high performance liquid chromatography and mass spectrometry