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Coronary artery disease progression after primary coronary artery bypass grafting may, beside classical atherosclerosis risk factors, be depending on genetic predisposition.    Methods  We investigated 192 CABG patients (18% female, age: 60.9 ± 7.4 years). Clinically cardiac adverse events were defined as need for reoperation (n = 88; 46%), reintervention (n = 58; 30%), or angina (n = 89; 46%). Mean follow-up time measured 10.1 ± 5.1 years. Gene polymorphisms (  ApoE, NOS3, LIPC, CETP, SERPINE-1, Prothrombin  ) were investigated separately and combined (gene risk profile).    Results  Among classical risk factors, arterial hypertension and hypercholesterinemia significantly influenced CAD progression. Single   ApoE, NOS3   and   LIPC   polymorphisms provided limited information. Patients missing the most common   ApoE   ε3 allele (5,2%), showed recurrent symptoms (p = 0,077) and had more frequently reintervention (p = 0,001).   NOS3   a allele was associated with a significant increase for reintervention (p = 0,041) and recurrent symptoms (p = 0,042).  Homozygous   LIPC   patients had a higher reoperation rate (p = 0.049).  A gene risk profile enabled us to discriminate between faster and slower occurrence of cardiac adverse events (p = 0.0012).    Conclusion  Single   APOE, LIPC   and   NOS3   polymorphisms permitted limited prognosis of cardiac adverse events in patients after CABG. Risk profile, in contrast, allowed for risk stratification.

Gene polymorphisms in APOE, NOS3, and LIPC genes may be risk factors for cardiac adverse events after primary CABG