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The transcription factor FOXP3 is essential for the development and function of CD4 + CD25 hi FOXP3 +  regulatory T (T reg ) cells, but also expressed in activated human helper T cells without acquisition of a regulatory phenotype. This comment focuses on glycoprotein-A repetitions predominant (GARP or LRRC32) recently identified as specific marker of activated human T reg  cells, which may provide the missing link toward a better molecular definition of the regulatory phenotype.  Reviewers: Dr Jim Di Danto, Dr Benedita Rocha and Dr Werner Solbach.

FOXP3 and GARP (LRRC32): the master and its minion