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Background  The NADH-ubiquinone oxidoreductase flavoprotein gene ( NDUFV2 ), which encodes a 24 kD mitochondrial complex I subunit, has been reported to be positively associated with schizophrenia and bipolar disorder in different populations.    Methods  We genotyped the promoter variants of this gene (rs6506640 and rs1156044) by direct sequencing in 529 unrelated Han Chinese schizophrenia patients and 505 matched controls. Fisher's Exact test was performed to assess whether these two reported single nucleotide polymorphisms (SNPs) confer susceptibility to schizophrenia in Chinese.    Results  Allele, genotype and haplotype comparison between the case and control groups showed no statistical significance, suggesting no association between the  NDUFV2  gene promoter variants and schizophrenia in Han Chinese.    Conclusion  The role of NDUFV2 played in schizophrenia needs to be further studied. Different racial background and/or population substructure might account for the inconsistent results between studies.

Common promoter variants of the NDUFV2 gene do not confer susceptibility to schizophrenia in Han Chinese