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Background  Ischemic hypoxic brain injury often causes irreversible brain damage. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional medicines. From the point of view of "self-medication" or "preventive medicine,"  Cordyceps sinensis  was used in the prevention of cerebral ischemia in this paper.    Methods  The right middle cerebral artery occlusion model was used in the study. The effects of  Cordyceps sinensis  (Caterpillar fungus) extract on mortality rate, neurobehavior, grip strength, lactate dehydrogenase, glutathione content, Lipid Peroxidation, glutathione peroxidase activity, glutathione reductase activity, catalase activity, Na + K + ATPase activity and glutathione S transferase activity in a rat model were studied respectively.    Results   Cordyceps sinensis  extract significantly improved the outcome in rats after cerebral ischemia and reperfusion in terms of neurobehavioral function. At the same time, supplementation of  Cordyceps sinensis  extract significantly boosted the defense mechanism against cerebral ischemia by increasing antioxidants activity related to lesion pathogenesis. Restoration of the antioxidant homeostasis in the brain after reperfusion may have helped the brain recover from ischemic injury.    Conclusions  These experimental results suggest that complement  Cordyceps sinensis  extract is protective after cerebral ischemia in specific way. The administration of  Cordyceps sinensis  extract significantly reduced focal cerebral ischemic/reperfusion injury. The defense mechanism against cerebral ischemia was by increasing antioxidants activity related to lesion pathogenesis.

Protective effect of extract of Cordyceps sinensis in middle cerebral artery occlusion-induced focal cerebral ischemia in rats