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Background  A number of studies have found associations between dysbindin ( DTNBP1 ) polymorphisms and schizophrenia. Recently we identified a  DTNBP1  SNP (rs9370822) that is strongly associated with schizophrenia. Individuals diagnosed with schizophrenia were nearly three times as likely to carry the CC genotype compared to the AA genotype.    Methods  To investigate the importance of this SNP in the function of  DTNBP1 , a number of psychiatric conditions including addictive behaviours and anxiety disorders were analysed for association with rs9370822.    Results  The  DTNBP1  polymorphism was significantly associated with post-traumatic stress disorder (PTSD) as well as nicotine and opiate dependence but not alcohol dependence. Individuals suffering PTSD were more than three times as likely to carry the CC genotype compared to the AA genotype. Individuals with nicotine or opiate dependence were more than twice as likely to carry the CC genotype compared to the AA genotype.    Conclusions  This study provides further support for the importance of  DTNBP1  in psychiatric conditions and suggests that there is a common underlying molecular defect involving  DTNBP1  that contributes to the development of several anxiety and addictive disorders that are generally recognised as separate clinical conditions. These disorders may actually be different expressions of a single metabolic pathway perturbation. As our participant numbers are limited our observations should be viewed with caution until they are independently replicated.

A polymorphism in the dysbindin gene (DTNBP1) associated with multiple psychiatric disorders including schizophrenia