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Background Clinical studies demonstrate that insomnia and alcoholism are significantly associated [1]. We have previously shown that experimental insomnia causes oxidative stress in rats [2]. Ethanol is known to induce xanthine oxidase (XO) activity leading to excessive free radicals generation. High free radical levels are associated to cognitive decline [3]. We investigated the effects of the simultaneous application of experimental alcoholism and insomnia on the oxidative status and cognitive functions of male rats.

Experimental models of insomnia and alcoholism: cognitive abilities and oxidative stress levels