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Background  There has been a recent resurgent interest in bacteriophage biology. Research was initiated to examine  Campylobacter jejuni -specific bacteriophage in the Russian Federation to develop alternative control measures for this pathogen.    Results  A  C. jejuni  flagellum-specific phage PV22 from  Proteus vulgaris  was identified in sewage drainage. This phage interacted with  C. jejuni  by attachment to flagella followed by translocation of the phage to the polar region of the bacterium up to the point of DNA injection. Electron microscopic examination revealed adsorption of PV22 on  C. jejuni  flagella after a five minute incubation of the phage and bacteria. A different phenomenon was observed after incubating the mix under the same conditions, but for twenty minutes or longer. Phage accumulated primarily on the surface of cells at sites where flagella originated. Interestingly, PV22 did not inject DNA into  C. jejuni  and PV22 did not produce lytic plaques on medium containing  C. jejuni  cells. The constant of velocity for PV22 adsorption on cells was 7 × 10 -9  ml/min.    Conclusion  It was demonstrated that a bacteriophage that productively infects  P. vulgaris  was able to bind  C. jejuni  and by a spot test that the growth of  C. jejuni  was reduced relative to control bacteria in the region of phage application. There may be two interesting applications of this effect. First, it may be possible to test phage PV22 as an antimicrobial agent to decrease  C. jejuni  colonization of the chicken intestine. Second, the phage could potentially be utilized for investigating biogenesis of  C. jejuni  flagella.

The ability of flagellum-specific Proteus vulgaris bacteriophage PV22 to interact with Campylobacter jejuni flagella in culture.