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Papillary thyroid carcinoma (PTC) composed by predominant solid areas is diagnosed as a distinct variant on histological samples. Here we present a case of PTC recognized preoperatively by fine needle cytology as a solid variant. This diagnosis was made by combining cytology with the detection of the BRAF VK600-1E  mutation, the molecular hallmark of the solid variant of PTC. Histological and molecular evaluation of the surgical specimen confirmed this pre-operative diagnosis. Thus combining cytology to  BRAF  molecular analysis is useful to refine the cytological diagnosis of this variant also on FNC specimens.

Cytological and molecular diagnosis of solid variant of papillary thyroid carcinoma: A case report