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Background We have hypothesized that membrane-bound macromolecular HIV-envelope proteins (mHIV-env) as a subunit, with gp120 and gp41 in their innate conformation, can be used as an effective immunogen to elicit broadly neutralizing antibodies (bnAb) against sexually or perinatally transmitted HIV-1. To test this hypothesis we have synthesized infection-free mHIV-env from the HIV-1 transmitted in humans (Vyas et al, Biologicals 2012;40:15-20). The process has been simplified for making large amounts of mHIV-env coupled with DC-SIGN expressing virus-like lipoparticles (VLP) as a candidate immunogen.

Virus-like particles highly expressing DC-SIGN concentrate trimeric HIV-envelope proteins with noncovalently linked immunoreactive gp120 and gp41