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Background  Cell migration is essential during development and in human disease progression including cancer. Most cell migration studies concentrate on known or predicted components of migration pathways.    Results  Here we use data from a genome-wide RNAi morphology screen in  Drosophila melanogaster  cells together with bioinformatics to identify 26 new regulators of morphology and cytoskeletal organization in human cells. These include genes previously implicated in a wide range of functions, from mental retardation, Down syndrome and Huntington's disease to RNA and DNA-binding genes. We classify these genes into seven groups according to phenotype and identify those that affect cell migration. We further characterize a subset of seven genes,  FAM40A, FAM40B, ARC, FMNL3, FNBP3/FBP11, LIMD1  and  ZRANB1 , each of which has a different effect on cell shape, actin filament distribution and cell migration. Interestingly, in several instances closely related isoforms with a single  Drosophila  homologue have distinct phenotypes. For example,  FAM40B  depletion induces cell elongation and tail retraction defects, whereas  FAM40A  depletion reduces cell spreading.    Conclusions  Our results identify multiple regulators of cell migration and cytoskeletal signalling that are highly conserved between  Drosophila  and humans, and show that closely related paralogues can have very different functions in these processes.

Identification and characterization of a set of conserved and new regulators of cytoskeletal organization, cell morphology and migration