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Familial Mediterranean fever (FMF) is an inherited autoinflammatory disorder characterized by recurring attacks of fever accompanied by intense pain in the abdomen, chest, or joints. Colchicine, is an important drug which is used in diseases such as FMF and acute gout attacks. However, it has significant side effects such as diarrhea, nausea, vomiting and fatigue. Some of the patients does not respond to treatment due to resistance. Therefore it is important to measure the serum levels of colchicine. The expected serum levels of colchicine is about 5-15 ng/ml. Correct measurement of this level with the classical analytical methods are not easy. Phase extraction and sample concentration of colchicine in routine laboratory conditions is time-consuming, so advanced analytical instruments such as LC-MS/MS and easy sample preparation methods are needed.

Colchicine measurement using LC-MS/MS with ESI in serum with liquid liquid extraction