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p < 0.005)], higher indexed LV mass by CMR (90.0 ± 35.5g/m 2 vs 63.2 ± 18.6 g/m 2 ,p<0 .0001), lower LV ejection fraction by CMR (63.7 ± 14.0 vs 69.1 ± 11.6, p = .047), and larger indexed LV end-diastolic volume by CMR (93.7 ± 20.2 ml/m 2 vs 79.7 ± 19.0 ml/m 2 , p <0.0001) compared with patients without myocardial fibrosis. Conclusions Myocardial fibrosis is associated with more severe calcific AS, worse LV functional parameters and higher LV mass index in patients with severe AS. From these results, contrast-enhanced CMR may provide new strategies for the earlier diagnosis of severe AS with myocardial

Significance of myocardial fibrosis on cardiac function and morphology in severe aortic stenosis