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Conventional MR angiography (MRA) exploits the property of exogenous contrast agents to shorten the T1 relaxation time. However, undesirable signal from surrounding tissue due to T1 recovery remains. IRON MRA is a promising off-resonance imaging technique, and provides in conjunction with superparamagnetic nanoparticles high intravascular contrast between the blood-pool and background tissue without need for image subtraction while T1 recovery of the surrounding tissue is no longer a problem.

journal of cardiovascular magnetic resonance

IRON magnetic resonance: a robust technique for angiography providing high blood-to-tissue contrast within the clinically approved dosage of superparamagnetic nanoparticles