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Methods Fourteen patients (mean age 33.1 ± 17.6 years, 9 male) were retrospectively identified from CMR database between December 2007 and May 2010. CMR imaging included SSFP cine in standard views and late gadolinium enhancement. Quantitative analysis included left and right ventricular function, volumes, mass, LV wall motion score and non-compacted to compacted myocardium (NC/C) ratios in different segments. Number of involved LV segments and regions of maximum NC/C ratio were also recorded. Patient’s medical records were reviewed for clinical history including NYHA functional class, ECG, telemetry, Holter/event monitoring and electrophysiology studies. Non-parametric U test, logistic regression analysis and parametric T-test were used to determine statistical significance as appropriate. Results Seven patients presented with acute heart failure including one in cardiogenic shock. Three patients presented with syncope, one with documented ventricular tachycardia (VT). Mean LVEF was 36.2 ± 22.8% and mean RVEF 31.5 ± 16.7%. LVEF <50% was present in 8 patients (57.1%), RVEF <40% in 7 (50%) and both in 6 (42.8%) patients. Mean NC/C myocardium ratio was 3.7±0.8 with mean of 5.5±3.1 LV segments involved. Patients with LV dysfunction were older, more symptomatic with higher NYHA class, had more myocardial segments involvement with non-compaction, and higher NC/C ratios (Table 1). No myocardial infarction or mid-wall fibrosis was seen on late gadolinium enhancement. One patient had thrombus in the right ventricle associated with severe RV dysfunction. Four patients had non-sustained monomorphic VT. Two patients had premature ventricular complexes on

CMR of LV non-compaction cardiomyopathy: association of clinical presentation and prognosis with cardiac phenotype