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Na + /K + -ATPase alpha 2 (Atp1a2) is an integral plasma membrane protein belonging to the P-type ATPase family that is responsible for maintaining the sodium (Na + ) and potassium (K + ) gradients across cellular membranes with hydrolysis of ATP. Atp1a2 contains two subunits, alpha and beta, with each having various isoforms and differential tissue distribution. In humans, mutations in  ATP1A2  are associated with a rare form of hereditary migraines with aura known as familial hemiplegic migraine type II. Genetic studies in mice have revealed other neurological effects of  Atp1a2  in mice including anxiety, fear, and learning and motor function disorders. This paper reviews the recent findings in the literature concerning  Atp1a2 .

Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models