English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Asthma is a chronic disorder leading to bronchial obstruction in response to inhaled allergen. It is associated with immune deregulation with specific expansion of Th2 and Th17 CD4+ T cells. Both T cell populations support B cells response by stimulating their proliferation, survival and IgE secretion. B cells are described for their effector functions but recently reports have described their regulatory role in autoimmune and inflammatory disorders. However, definitive identification has been challenging because regulatory B cells (Breg) are rare, do not have a specific marker, and express detectable IL-10 or TGF-β only upon ex vivo stimulation. In OVA asthma models, local inhalation tolerance [1], [2] and infections with helminthes [3], [4] induce the generation of regulatory B cells. But no physiological role of this population in the development of asthma has been described yet.

Deficiency of regulatory B cells in a house dust mite model of asthma