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Background  Allergen-induced imbalance of specific T regulatory (Treg) cells and T helper 2 cells plays a decisive role in the development of immune response against allergens.    Objective  To evaluate effects and potential mechanisms of DNA vaccine containing ovalbumin (OVA) and Fc fusion on allergic airway inflammation.    Methods  Bronchoalveolar lavage (BAL) levels of inflammatory mediators and leukocyte infiltration, expression of CD 11c  + CD 80  +  and CD 11c  + CD 86  +  co-stimulatory molecules in spleen dendritic cells (DCs), circulating CD 4  +  and CD 8  +  T cells, Foxp3 +  in spleen CD 4  +  T cells and spleen CD 4  +  T cells were measured in OVA-sensitized and challenged animals pretreated with pcDNA, OVA-pcDNA, Fc-pcDNA, and OVA-Fc-pcDNA.    Results  OVA-Sensitized and challenged mice developed airway inflammation and Th2 responses, and decreased the proliferation of peripheral CD 4  + and CD 8  +  T cells and the number of spleen Foxp 3  +  Treg. Those changes with increased INF-γ production and reduced OVA-specific IgE production were protected by the pretreatment with OVA-Fc-pcDNA.    Conclusion  DNA vaccine encoding both Fc and OVA showed more effective than DNA vaccine encoding Fc or OVA alone, through the balance of DCs and Treg.

genetic vaccines and therapy

Protection against the allergic airway inflammation depends on the modulation of spleen dendritic cell function and induction of regulatory T cells in mice