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Background  Previous studies reported the relation between  MTLRP  genetic polymorphism and type 2 diabetes, however, the conclusion were conflicting. In the present study, we performed a meta-analysis to reveal this association.    Methods  Literature retrieval, selection and assessment, data extraction, and meta-analyses were performed according to the RevMan 5.0 guidelines. In the meta-analysis, we utilized random-effect model or fixed-effect model to pool the Odds ratio (OR) according to the test of heterogeneity.    Results  A total of nine case–control studies included 4460 type 2 diabetes patients and 4114 healthy control subjects were analyzed. We did not found association between the  MTLRP  polymorphism and type 2 diabetes risk in the overall population (CC  vs  CA + AA: OR = 1.02; 95% CI: 0.89-1.17, P = 0.77; A  vs  C: OR = 1.02; 95% CI: 0.84-0.96, P = 0.62). However, in subgroup analyses stratified by ethnicity, we found significant association of MTLRP polymorphism with type 2 diabetes in Caucasians (CC  vs  CA + AA: OR = 1.27; 95% CI: 1.02-1.57, P = 0.03; A  vs  C: OR = 0.74, 95% CI: 0.60–0.91, P = 0.005).    Conclusion  The  MTLRP  polymorphism was associated with type 2 diabetes in Caucasians.

MTLRP genetic polymorphism (214C>A) was associated with Type 2 diabetes in Caucasian population: a meta-analysis