English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Introduction  Apolipoprotein A1 (apoA1) is the major apoprotein constituent of high density lipoprotein (HDL) which exerts innate protective effects in systemic inflammation. However, its role in the acute lung injury (ALI) or acute respiratory distress syndrome (ARDS) has not been well studied. The objective of this study was to investigate the potential association between  APOA1  -75 G/A polymorphism and the development of ALI after cardiopulmonary bypass (CPB) surgery.    Materials and methods  A hospital-based case–control study was conducted in patients with ALI (n = 300), patients without ALI (n = 300) and healthy controls (n = 300). Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) assay was applied to assess the  APOA1  -75 G/A genotypes.    Results  Patients with ALI had a significantly higher frequency of  APOA1  -75 AA genotype [odds ratio (OR) =1.75, 95% confidence interval (CI) = 1.04, 2.92;  P  = 0.03] than patients without ALI.  APOA1  -75 AA genotype (OR =3.47, 95% CI = 1.60, 7.52;  P =  0.002) and A allele (OR =1.92, 95% CI = 1.24, 2.96;  P =  0.003) were the significant independent prognostic factors for the 30-day survival rate of patients with ALI after CPB surgery.    Conclusion  Our study suggested that  APOA1  -75 AA genotype was associated with a higher ALI risk after CPB surgery. Patients with the  APOA1  -75 AA genotype and A allele had higher 30-day mortality of ALI after CPB surgery. Additional studies are needed to confirm this finding.

Association of apolipoprotein A1 -75 G/A polymorphism with susceptibility to the development of acute lung injury after cardiopulmonary bypass surgery