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Background  Our previous study demonstrated that the A-allele of the single nucleotide polymorphism (SNP) rs34623097 located in the upstream region of the β2 adrenergic receptor gene ( ADRB2 ) is significantly associated with risk for obesity in Oceanic populations.    Methods  To investigate whether the  ADRB2  polymorphisms explain part of the individual differences in lipid mobilization, energy expenditure and glycogen breakdown, the associations of 10  ADRB2  SNPs with total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and triglyceride levels were examined in 128 adults in Tonga.    Results  A multiple linear regression analysis adjusted for age, sex, and body mass index revealed that rs34623097 was significantly associated with triglyceride levels ( P -value = 0.037). A copy of the rs34623097-A allele increased serum triglyceride levels by 70.1 mg/dL (0.791 mmol/L). None of the  ADRB2  SNPs showed a significant association with total-cholesterol, high-density lipoprotein cholesterol, or low-density lipoprotein cholesterol.    Conclusions  In a Tongan population, a SNP located in the upstream region of  ADRB2  is associated with triglyceride levels independent of body mass index.

Association of ADRB2 polymorphism with triglyceride levels in Tongans