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Background  The aim of the present study was to analyze the expression of eukaryotic translation initiation factor 4 gamma 1 ( EIF4G1 ) in nasopharyngeal carcinoma (NPC) and its correlation with clinicopathologic features, including patients' survival time.    Methods  Using real-time PCR, we detected the expression of  EIF4G1  in normal nasopharyngeal tissues, immortalized nasopharyngeal epithelial cell lines NP69, NPC tissues and cell lines.  EIF4G1  protein expression in NPC tissues was examined using immunohistochemistry. Survival analysis was performed using Kaplan-Meier method. The effect of  EIF4G1  on cell invasion and tumorigenesis were investigated.    Results  The expression levels of  EIF4G1  mRNA were significantly greater in NPC tissues and cell lines than those in the normal nasopharyngeal tissues and NP69 cells ( P  < 0.001). Immunohistochemical analysis revealed that the expression of  EIF4G1  protein was higher in NPC tissues than that in the nasopharyngeal tissues ( P  < 0.001). In addition, the levels of  EIF4G1  protein in tumors were positively correlated with tumor T classification ( P  = 0.039), lymph node involvement (N classification,  P  = 0.008), and the clinical stages ( P  = 0.003) of NPC patients. Patients with higher  EIF4G 1 expression had shorter overall survival time ( P  = 0.019). Multivariate analysis showed that  EIF4G1  expression was an independent prognostic indicator for the overall survival of NPC patients. Using shRNA to knock down the expression of  EIF4G1  not only markedly inhibited cell cycle progression, proliferation, migration, invasion, and colony formation, but also dramatically suppressed  in vivo  xenograft tumor growth.    Conclusion  Our data suggest that  EIF4G1  can serve as a biomarker for the prognosis of NPC patients.

Over-expression of eukaryotic translation initiation factor 4 gamma 1 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma