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Materials and methods Fresh fruits were collected by an ethnobotanist in Yaounde area in May 2009. The plant was dried at Room Temperature during 7 days, powdered and extracted using organic solvents. The extract was fractionated by flash chromatography over silica gel (70-230 mesh, Merck, 7 x 42 cm), eluting with gradients of hexane-ethyl acetate mixtures, and resulted in 35 fractions, which were pooled on the basis of thin layer chromatography patterns. Resulting fractions were tested in vitro against the Plasmodium falciparum chloroquine-resistant strain W2, and the recombinant cysteine protease Falcipain 2 (F2) [1]. Two fractions showed the best potency and were selected for phytochemical investigation guided by biological activity.

malaria journal

Falcipain 2 inhibitors and antiplasmodial compounds from a bio-guided fractionation of the fruits of Sorindeia juglandifolia A. Rich. (Anacardiaceae) growing in Cameroon