English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Background  In insects, including  Anopheles  mosquitoes, Dscam (Down syndrome cell adhesion molecule) appears to be involved in phagocytosis of pathogens, and shows pathogen-specific splice-form expression between divergent pathogen (or parasite) types (e.g. between bacteria and  Plasmodium  or between  Plasmodium berghei  and  Plasmodium falciparum ). Here, data are presented from the first study of  Dscam  expression in response to genetic diversity within a parasite species.    Methods  In independent field and laboratory studies, a measure of Dscam splice-form diversity was compared between mosquitoes fed on blood that was free of  P. falciparum  to mosquitoes exposed to either single or mixed genotype infections of  P. falciparum.Results  Significant increases in  Anopheles gambiae  Dscam (AgDscam) receptor diversity were observed in parasite-exposed mosquitoes, but only weak evidence that AgDscam diversity rises further upon exposure to mixed genotype parasite infections was found. Finally, a cluster of  AgDscam  exon 4 variants that become especially common during  Plasmodium  invasion was identified.    Conclusions  While the data clearly indicate that AgDscam diversity increases with  P. falciparum  exposure, they do not suggest that AgDscam diversity rises further in response to increased parasite diversity.

Alternative splicing of the Anopheles gambiae Dscam gene in diverse Plasmodium falciparum infections