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Background and methods  In order to characterize the expression pattern of  SALL4 ,  BMI-1  and ABCA3 genes in patients with myeloid leukemia and those who achieved complete remission (CR) after chemotherapy. Real-time PCR was used to determine the expression level of these genes in peripheral blood mononuclear cells from 24 patients with AML, eight patients with AML-CR, 13 patients with CML in the chronic phase (CML-CP), 12 patients with CML in blast crisis (CML-BC), 13 patients with CML-CR and 11 healthy individuals (HI).    Results  Overexpression of the  BMI-1  gene was found in the AML, CML-CP and CML-BC groups as compared with HI group, while the BMI-1 expression level was lower in patients who achieved CR. In contrast, significantly increased  SALL4  expression was only found in AML group, additionally,  SALL4  expression was lower in the CML-CP and CML-CR groups compared with the HI group, while the  SALL4  expression level in the CML-BC group was higher and significantly greater than that in the CML-CP and CML-CR groups. Moreover, a positive correlation between the expression of  SALL4 and BMI-1  genes was found in samples from most groups. There was no significant difference of  ABCA3  expression level in AML and CML-BC group in comparison with HI group. Interestingly, the  ABCA3  expression level was significantly decreased in the CML-CP, AML-CR and CML-CR in comparison with the HI group. Moreover, the  ABCA3  expression level in all of the CR groups was lower than that in their corresponding groups.    Conclusions  These results describe the altered  SALL4, ABCA3  and  BMI-1  expression pattern in different phases of myeloid leukemia, which may relate to the development and progression to different diseases.  SALL4  expression was strongly correlated with  BMI-1  in most of the myeloid leukemia patient groups, providing a potential link between  SALL4  and  BMI-1  in leukemogenesis.

The differential expression pattern of the BMI-1, SALL4 and ABCA3 genes in myeloid leukemia