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Background  In this report the phytochemical profile of  Nitraria. Retusa (N. Retusa ) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated.    Methods  Apoptosis of the human chronic myelogenous erythroleukaemia (K562) was evidenced by investigating DNA fragmentation, PARP cleavage and caspases 3 and 8 inducing activities, in the presence of  N. retusa  extracts.    Results  Our study revealed that the tested extracts from  N. Retusa  contain many useful bioactive compounds. They induced in a time-dependent manner the apoptosis the tested cancerous our cell line. This result was confirmed by ladder DNA fragmentation profile and PARP cleavage, as well as a release in caspase-3 and caspase-8 level.    Conclusion  Our results indicate that the tested compounds have a significant antiproliferative effect which may be due to their involvement in the induction of the extrinsic apoptosic pathway.

Leaf extracts from Nitraria retusa promote cell population growth of human cancer cells by inducing apoptosis