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Background  Human immune cells generate large amounts of reactive oxygen species (ROS) throughout the respiratory burst that occurs during inflammation. In inflammatory bowel diseases, a sustained and abnormal activation of the immune system results in oxidative stress in the digestive tract and in a loss of intestinal homeostasis. We previously showed that the heterologous production of the  Lactobacillus plantarum  ATCC14431 manganese-dependant catalase (MnKat) in  Lb. casei  BL23 successfully enhances its survival when exposed to oxidative stress. In this study, we evaluated the preventive effects of this antioxidative  Lb. casei  strain in a murine model of dextran sodium sulfate (DSS)-induced moderate colitis.    Results  Either  Lb. casei  BL23 MnKat -  or MnKat +  was administered daily to mice treated with DSS for 10 days. In contrast to control mice treated with PBS for which DSS induced bleeding diarrhea and mucosal lesions, mice treated with both  Lb. casei  strains presented a significant ( p  < 0.05) reduction of caecal and colonic inflammatory scores.    Conclusion  No contribution of MnKat to the protective effect from epithelial damage has been observed in the tested conditions. In contrast, these results confirm the high interest of  Lb. casei  as an anti-inflammatory probiotic strain.

Anti-inflammatory effects of Lactobacillus casei BL23 producing or not a manganese-dependant catalase on DSS-induced colitis in mice