English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Although oxidative stress by accumulation of reactive oxygen species (ROS) in diabetes has become evident, it remains unclear what genes, involved in redox balance, would determine susceptibility for development of atherosclerosis in diabetes. This study evaluated the effect of genetic polymorphism of enzymes producing or responsible for reducing ROS on coronary artery calcification in type 2 diabetes (T2D).    Methods  An index for coronary-arteriosclerosis, coronary artery calcium score (CACS) was evaluated in 91 T2D patients using a multi-slice computed tomography. Patients were genotyped for ROS-scavenging enzymes,  Glutathione peroxidase-1 (GPx-1) ,  Catalase, Mn-SOD ,  Cu/Zn-SOD , as well as SNPs of  NADPH oxidase  as ROS-promoting elements, genes related to onset of T2D ( CAPN10, ADRB3, PPAR gamma, FATP4 ). Age, blood pressure, BMI, HbA 1c , lipid and duration of diabetes were evaluated for a multivariate regression analysis.    Results  CACS with Pro/Leu genotype of the  GPx-1  gene was significantly higher than in those with Pro/Pro (744 ± 1,291 vs. 245 ± 399, respectively,  p  = 0.006). In addition, genotype frequency of Pro/Leu in those with CACS ≥ 1000 was significantly higher than in those with CACS < 1000 (45.5% vs. 18.8%;  OR  = 3.61,  CI  = 0.97–13.42;  p  = 0.045) when tested for deviation from Hardy-Weinberg's equilibrium. Multivariate regression analyses revealed that CACS significantly correlated with  GPx-1  genotypes and age.    Conclusion  The presence of Pro197Leu substitution of the  GPx-1  gene may play a crucial role in determining genetic susceptibility to coronary-arteriosclerosis in T2D. The mechanism may be associated with a decreased ability to scavenge ROS with the variant  GPx-1 .

cardiovascular diabetology

Genetic association of glutathione peroxidase-1 with coronary artery calcification in type 2 diabetes: a case control study with multi-slice computed tomography