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Background   Staphylococcus  genus is widely spread in nature being part of the indigenous microbiota of skin and mucosa of animal and birds. Some  Staphylococcus  species are frequently recognized as etiological agents of many animal and human opportunistic infections This is the first report testing the antibiotic resistance-modifying activity of  Turnera ulmifolia  against methicillin-resistant  Staphylococcus aureus  – MRSA strain.    Methods  In this study an ethanol extract of  Turnera ulmifolia  L. and chlorpromazine were tested for their antimicrobial activity alone or in combination with aminoglycosides against an MRSA strain.    Results  The synergism of the ethanol extract and aminoglycosides were verified using microdillution method. A synergistic effect of this extract on gentamicin and kanamycin was demonstrated. Similarly, a potentiating effect of chlorpromazine on kanamycin, gentamicin and neomycin, indicating the involvement of an efflux system in the resistance to these aminoglycosides.    Conclusion  It is therefore suggested that extracts from  Turnera ulmifolia  could be used as a source of plant-derived natural products with resistance-modifying activity, constituting a new weapon against the problem of bacterial resistance to antibiotics demonstrated in MRSA strains.

bmc complementary and alternative medicine

Herbal therapy associated with antibiotic therapy: potentiation of the antibiotic activity against methicillin – resistant Staphylococcus aureus by Turnera ulmifolia L