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Background   Thuja orientalis  has been traditionally used to treat patients who suffer from baldness and hair loss in East Asia. The present study sought to investigate the hair growth-promoting activity of  T .  orientalis  hot water extract and the underlying mechanism of action.    Methods  After  T .  orientalis  extract was topically applied to the shaved dorsal skin of telogenic C57BL/6 N mice, the histomorphometric analysis was employed to study induction of the hair follicle cycle. To determine the effect of  T .  orientalis  extract on the telogen to anagen transition, the protein expression levels of β-catenin and Sonic hedgehog (Shh) in hair follicles were determined by immunohistochemistry.    Results  We observed that  T .  orientalis  extract promoted hair growth by inducing the anagen phase in telogenic C57BL/6 N mice. Specifically, the histomorphometric analysis data indicates that topical application of  T .  orientalis  extract induced an earlier anagen phase and prolonged the mature anagen phase, in contrast to either the control or 1% minoxidil-treated group. We also observed increases in both the number and size of hair follicles of the  T .  orientalis  extract-treated group. Moreover, the immunohistochemical analysis reveals earlier induction of β-catenin and Shh proteins in hair follicles of the  T .  orientalis  extract-treated group, compared to the control or 1% minoxidil-treated group.    Conclusion  These results suggest that  T .  orientalis  extract promotes hair growth by inducing the anagen phase in resting hair follicles and might therefore be a potential hair growth-promoting agent.

Hair growth-promoting activity of hot water extract of Thuja orientalis