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Background  The cattle ticks,  Boophilus  spp., affect cattle production in tropical and subtropical regions of the world. Tick vaccines constitute a cost-effective and environmentally friendly alternative to tick control. The recombinant  B. microplus  Bm86 protective antigen has been shown to protect cattle against tick infestations. Recently, the gene coding for  B. annulatus  Bm86 ortholog, Ba86, was cloned and the recombinant protein was secreted and purified from the yeast  Pichia pastoris .    Results  Recombinant Ba86 (Israel strain) was used to immunize cattle to test its efficacy for the control of  B. annulatus  (Mercedes, Texas, USA strain) and  B. microplus  (Susceptible, Mexico strain) infestations. Bm86 (Gavac and Mozambique strain) and adjuvant/saline were used as positive and negative controls, respectively. Vaccination with Ba86 reduced tick infestations (71% and 40%), weight (8% and 15%), oviposition (22% and 5%) and egg fertility (25% and 50%) for  B. annulatus  and  B. microplus , respectively. The efficacy of both Ba86 and Bm86 was higher for  B. annulatus  than for  B. microplus . The efficacy of Ba86 was higher for  B. annulatus  (83.0%) than for  B. microplus  (71.5%). The efficacy of Bm86 (Gavac; 85.2%) but not Bm86 (Mozambique strain; 70.4%) was higher than that of Ba86 (71.5%) on  B. microplus . However, the efficacy of Bm86 (both Gavac and Mozambique strain; 99.6%) was higher than that of Ba86 (83.0%) on  B. annulatus .    Conclusion  These experiments showed the efficacy of recombinant Ba86 for the control of  B. annulatus  and  B. microplus  infestations in cattle and suggested that physiological differences between  B. microplus  and  B. annulatus  and those encoded in the sequence of Bm86 orthologs may be responsible for the differences in susceptibility of these tick species to Bm86 vaccines.

Vaccination with recombinant Boophilus annulatus Bm86 ortholog protein, Ba86, protects cattle against B. annulatus and B. microplus infestations