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Background  The Catechol- O -methyltransferase ( COMT ) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype.    Methods  In the 1995–97 Nord-Trøndelag Health Study (HUNT), the association between Val/Met polymorphism at the  COMT  gene and chronic musculoskeletal complaints (MSCs) was evaluated in a random sample of 3017 individuals.    Results  The distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar between controls and the chronic MSCs groups.    Conclusion  In this population-based study, no significant association was found between Val/Met polymorphism at the  COMT  gene and chronic MSCs.

No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study