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Background  This study reports on clinical data from an 8-week open-label study of 20 HIV-seropositive individuals, diagnosed with Major Depressive Disorder (DSM-IV), who were treated with SAM-e (S-Adenosylmethionine). SAM-e may be a treatment alternative for the management of depression in a population reluctant to add another "pill" or another set of related side effects to an already complex highly active antiretroviral therapy (HAART) regimen.    Methods  The Hamilton Rating Scale for Depression (HAM-D) and the Beck Depression Inventory (BDI) were used to assess depressive symptomatology from 1,2,4,6 and 8 weeks after initiation of treatment with SAM-e.    Results  Data show a significant acute reduction in depressive symptomatology, as measured by both the HAM-D and the BDI instruments.    Conclusions  SAM-e has a rapid effect evident as soon as week 1 ( p  < .001), with progressive decreases in depression symptom rating scores throughout the 8 week study.

S-adenosylmethionine (SAM-e) for the treatment of depression in people living with HIV/AIDS