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Background  The incidence of community-associated methicillin-resistant  Staphylococcus aureus  (MRSA) has risen dramatically in the U.S., particularly among children. Although  Streptococcus pneumoniae  colonization has been inversely associated with  S. aureus  colonization in unvaccinated children, this and other risk factors for  S. aureus  carriage have not been assessed following widespread use of the heptavalent pneumococcal conjugate vaccine (PCV7). Our objectives were to (1) determine the prevalence of  S. aureus  and MRSA colonization in young children in the context of widespread use of PCV7; and (2) examine risk factors for  S. aureus  colonization in the post-PCV7 era, including the absence of vaccine-type  S. pneumoniae  colonization.    Methods  Swabs of the anterior nares ( S. aureus ) were obtained from children enrolled in an ongoing study of nasopharyngeal pneumococcal colonization of healthy children in 8 Massachusetts communities. Children 3 months to <7 years of age seen for well child or sick visits in primary care offices from 11/03–4/04 and 10/06–4/07 were enrolled.  S. aureus  was identified and antibiotic susceptibility testing was performed. Epidemiologic risk factors for  S. aureus  colonization were collected from parent surveys and chart reviews, along with data on pneumococcal colonization. Multivariate mixed model analyses were performed to identify factors associated with  S. aureus  colonization.    Results  Among 1,968 children, the mean age (SD) was 2.7 (1.8) years, 32% received an antibiotic in the past 2 months, 2% were colonized with PCV7 strains and 24% were colonized with non-PCV7 strains. The prevalence of  S. aureus  colonization remained stable between 2003–04 and 2006–07 (14.6% vs. 14.1%), while MRSA colonization remained low (0.2% vs. 0.9%, p = 0.09). Although absence of pneumococcal colonization was not significantly associated with  S. aureus  colonization, age (6–11 mo vs. ≥5 yrs, OR 0.39 [95% CI 0.24–0.64]; 1–1.99 yrs vs. ≥5 yrs, OR 0.35 [0.23–0.54]; 2–2.99 yrs vs. ≥5 yrs, OR 0.45 [0.28–0.73]; 3–3.99 yrs vs. ≥5 yrs, OR 0.53 [0.33–0.86]) and recent antibiotic use were significant predictors in multivariate models.    Conclusion  In Massachusetts,  S. aureus  and MRSA colonization remained stable from 2003–04 to 2006–07 among children <7 years despite widespread use of pneumococcal conjugate vaccine.  S. aureus  nasal colonization varies by age and is inversely correlated with recent antibiotic use.

Epidemiology and risk factors for Staphylococcus aureuscolonization in children in the post-PCV7 era