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Background  Endophthalmitis is the inflammatory response to invasion of the eye with bacteria or fungi. The incidence of endophthalmitis after cataract surgery varies between 0.072–0.13 percent. Treatment of endophthalmitis with fungal etiology is difficult.    Case Presentation   Case 1:  A 71-year old male diabetic patient developed postoperative endophthalmitis due to  Aspergillus flavus . The patient was treated with topical amphotericin B ophthalmic solution, intravenous (IV) liposomal amphotericin-B and caspofungin following vitrectomy.   Case 2:  A 72-year old male cachectic patient developed postoperative endophthalmitis due to  Scopulariopsis  spp. The patient was treated with topical and IV voriconazole and caspofungin.    Conclusion   Aspergillus  spp. are responsible of postoperative fungal endophthalmitis. Endophthalmitis caused by  Scopulariopsis  spp. is a very rare condition. The two cases were successfully treated with local and systemic antifungal therapy.

Treatment of two postoperative endophthalmitis cases due to Aspergillus flavus and Scopulariopsis spp. with local and systemic antifungal therapy