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Background  GPR125 belongs to the family of  Adhesion  G protein-coupled receptors (GPCRs). A single copy of GPR125 was found in many vertebrate genomes. We also identified a  Drosophila  sequence, DmCG15744, which shares a common ancestor with the entire Group III of  Adhesio n GPCRs, and also contains Ig, LRR and HBD domains which were observed in mammalian GPR125.    Results  We found specific expression of GPR125 in cells of the choroid plexus using  in situ  hybridization and protein-specific antibodies and combined  in situ /immunohistochemistry co-localization using cytokeratin, a marker specific for epithelial cells. Induction of inflammation by LPS did not change GPR125 expression. However, GPR125 expression was transiently increased (almost 2-fold) at 4 h after traumatic brain injury (TBI) followed by a decrease (approximately 4-fold) from 2 days onwards in the choroid plexus as well as increased expression (2-fold) in the hippocampus that was delayed until 1 day after injury.    Conclusion  These findings suggest that GPR125 plays a functional role in choroidal and hippocampal response to injury.

The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury